Arizona Cardinals vs. Buffalo Bills Betting Odds, Analysis, NFL Pick

September 22, 2016   ·   OddsShark.com   ·   Jump to comments

Flying cross-country isn't normally conducive to success for NFL teams but the Arizona Cardinals are learning to buck that belief, going 12-5 against the spread over their past 17 games in the Eastern time zone. Arizona returns east when it visits the baffling Buffalo Bills on Sunday afternoon.
 
Point spread: The Cardinals opened as 5.5-point favorites and the total was 47 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
NFL pick, via Odds Shark computer: 22.4-18.6 Cardinals (NFL picks on every game)
 
Why the Cardinals can cover the spread
The Cardinals rebounded from that season-opening loss to New England to pound Tampa Bay last week 40-7, easily covering as seven-point favorites. That game was close until Arizona blew it open with two touchdowns in the last minute and a half of the second quarter, taking a 24-0 lead into halftime. The Cardinals let the Buccaneers pull within 24-...

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