Arizona Cardinals vs. San Francisco 49ers Betting Odds, Analysis, NFL Pick

October 5, 2016   ·   OddsShark.com   ·   Jump to comments

The Arizona Cardinals could be without injured quarterback Carson Palmer when they attempt to end a two-game straight up and against the spread losing streak Thursday night against the San Francisco 49ers at Levi's Stadium.
The Cardinals are coming off a pair of outright losses as favorites, opening at 1-3 SU for the first time since 2011 while going 2-5 SU and 1-6 ATS over their past seven contests.
Since a season-opening 28-0 rout of the Los Angeles Rams, the 49ers have sputtered. San Francisco has lost three straight, SU and ATS, and it is pegged as an underdog for its 11th-straight home contest.
      
Point spread: The Cardinals opened as 2.5-point favorites; the total was 43 early in the week, according to sportsbooks monitored by Odds Shark. Line updates and matchup report.
NFL pick, via Odds Shark computer: 22.0-21.5 Cardinals (NFL picks on every game)
      
Why the Cardinals can cover the spread
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