NFL Predictions Week 12: Top Underdog Picks, Vegas Odds and Score Predictions

November 25, 2015   ·   Andrew Gould   ·   Jump to comments

Don't anticipate any Thanksgiving miracles during Week 12's most lopsided NFL contests.
Of the 16 games in the league's first full slate since Week 3, three would max out the upset scale if the underdogs prevailed. The red-hot Arizona Cardinals take their explosive offense into San Francisco to face the 49ers, who lost by 40 when they last met. Look for the Super Bowl contenders to again dismantle a team holding the NFL's worst scoring margin.
The Cincinnati Bengal contain a lower floor than most 8-2 squads, and the St. Louis Rams have already conquered the Cardinals and Seattle Seahawks this season. While it's feasible, and the Rams could certainly cover a lofty spread, don't bank on Case Keenum leading a listless passing offense to victory.
The Green Bay Packers already suffered one upset to an unexpected NFC North foe, but it's highly unlikely they drop another division game at Lambeau Field. On a short week, the banged-up Chicago Bears aren't likely to even out a one...

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