San Francisco 49ers vs. Arizona Cardinals Betting Odds, Analysis, NFL Pick

September 24, 2015   ·   OddsShark.com   ·   Jump to comments

The worm may be turning in the rivalry between the 49ers and Cardinals; San Francisco has won 10 of the last 12 meetings between the teams, but Arizona is 4-3 against the spread over the last seven, including an ATS sweep of the series last season. First-place Arizona hosts the Niners Sunday afternoon.
 
Point spread: The Cardinals opened as six-point favorites; the total was 44.5 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
NFL pick, via Odds Shark computer: 29.1-20.3 Cardinals
 
Why the 49ers can cover the spread
San Francisco is 1-1 both SU and ATS so far this season after falling at Pittsburgh last week 43-18, whiffing on the cover as a six-point underdog. The 49ers only trailed 8-3 midway through the second quarter, but gave up three touchdowns over a seven-minute span to fall out of contention.
San Francisco actually outrushed the Steelers on the day 111-84, and quarterback...

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