San Francisco 49ers vs. Buffalo Bills Betting Odds, Analysis, NFL Pick

October 14, 2016   ·   OddsShark.com   ·   Jump to comments

The San Francisco 49ers will be looking to end a four-game straight-up and against-the-spread losing streak when they visit the Buffalo Bills on Sunday.
The 49ers have surrendered 35 points per game since opening with a 28-0 win over the Los Angeles Rams and are 1-9 SU and 2-8 ATS in their past 10 road contests. The Bills have claimed decisive victories in three straight games, including two outright wins as betting underdogs, and they are 14-2 SU and 10-6 ATS in their past 16 games when favored by nine or more points.
          
Point spread: The Bills opened as seven-point favorites; the total was 45.5 early in the week, according to sportsbooks monitored by Odds Shark (Line updates and matchup report).
NFL pick, via Odds Shark computer: 25.0-17.0 Bills (NFL picks on every game)
            
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